Ammonium formate → HCID 89647534, compound

Participants

Reaction Conditions

Reaction Steps

To 3-(benzyloxycarbonylamino-methyl)-3-phenylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1200.00 mg; 2.65 mmol; 1.00 eq.) in 30 ml of methanol was added of ammonium formate (1668.40 mg; 26.46 mmol; 10.00 eq.) and 10% Pd/C (wet) 1.2 g. The mixture was stirred at 65° C. for 1 hr and then filtered. The filtrate was concentrated to give the crude, which was dissolved in DCM and washed with 5% NaHCO3, brine, dried and concentrated to afford the title compound (820 mg, 97%).

Provenance & Evidence