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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2281020Generated: November 2, 2026

5-Amino-8-quinolinecarboxamide → 5-((3S)-3-phenylazetidine-2-carboxamido)quinoline-8-carboxamide

https://huagongshe.com/reaction/2281020

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Amino-8-quinolinecarboxamideHCID 89647225—
Reactant(3S)-1-(tert-butoxycarbonyl)-3-phenylazetidine-2-carboxylic acidHCID 89647751—
Product5-((3S)-3-phenylazetidine-2-carboxamido)quinoline-8-carboxamideHCID 89647980—

Reaction Steps

The title compound was synthesized according to the procedure described for the preparation of Example 27 by using 5-aminoquinoline-8-carboxamide coupled with (3S)-1-(tert-butoxycarbonyl)-3-phenylazetidine-2-carboxylic acid, followed by de-Boc to afford Example 30. LC-MS (M+H=347, obsd=347).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09139568B2
Source datasetuspto-grants-2015_09
ORD IDord-2e61de6e919d479b87b44fd2ca8ed3ae
Source noteuspto-grants-2015_09