Hydrochloric Acid → HCID 86711982, compound

Participants

Reaction Steps

Ethyl N-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}glycinate (42 mg, 0.097 mmol) was added to a dichloromethane:1 N hydrochloric acid solution (400 μL:80 μL) and the mixture placed into an ice-bath at 0° C. Potassium cyanate (24 mg, 0.29 mmol) was dissolved in deionized water (300 uL) and this solution was added to the mixture over 5 minutes. The mixture was vigorously stirred for 1.5 hours, at which time the mixture was treated with sodium bicarbonate (aqueous saturated) and extracted with ethyl acetate (3×40 mL). The organic layers were combined, dried with sodium sulfate, filtered and concentrated in vacuo to provide the titled compound.

Provenance & Evidence