Ammonia → HCID 56973649, compound

HRID 2281079Notes

Reaction equation

HRID 2281079 reaction equation
[Br:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1.[NH3:12]>C(O)C>[NH2:12][C:8]1[CH:9]=[C:2]([Br:1])[CH:3]=[C:4]([F:11])[C:5]=1[C:6]#[N:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27569164-Bromo-2,6-difluorobenzonitrile

Product 1

HCID 56973649HCID 56973649, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

5.0 g (22.9 mmol) 4-bromo-2,6-difluorobenzonitrile are dissolved in 200 ml of a solution of NH3 in ethanol and heated in a pressure vessel to 90° C. for 20 h. After cooling to RT the solvent is evaporated and the residual taken in up in water/DCM. The organic phase is separated, dried and evaporated.

Workup

  1. temperatureAfter cooling to RT the solvent
  2. customis evaporated
  3. customThe organic phase is separated
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-556228a38fce417492a28866cf533899
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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