2,4-Difluoronitrobenzene → HCID 117774749, compound

HRID 2281086Notes

Reaction equation

HRID 2281086 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-])=O.[CH3:12][C:13]1[CH:17]=[C:16]([C@H:18]([OH:20])[CH3:19])[O:15][N:14]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([NH2:9])=[C:2]([O:20][C@@H:18]([C:16]2[O:15][N:14]=[C:13]([CH3:12])[CH:17]=2)[CH3:19])[CH:7]=1

Participants

3

Reactant 2

HCID 679672,4-DifluoronitrobenzeneHCID 86316026HCID 86316026, compound

Product 1

HCID 117774749HCID 117774749, compound

Procedure

Yield: 0.7 g (33%), ESI-MS: m/z=128 (M+H)+, Rt(HPLC): 0.28 min (HPLC-G) III.5 was prepared in a similar manner as the racemate intermediate III.4 from 2,4-difluoro-1-nitro-benzene and (1R)-1-(3-methylisoxazol-5-yl)ethanol.

Sources & evidence

ORD record
ord-5d50de9b6cb44476a41872dbc68e8d9f
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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