HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Furfural | HCID 7362 | — |
| Reactant | Cyclohexyl isocyanide | HCID 79129 | — |
| Reactant | 2-Amino-5-(trifluoromethyl)pyridine | HCID 735862 | — |
| Solvent | Perchloric Acid | HCID 24247 | — |
| Product | N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide | HCID 9865235 | — |
Reaction Steps
Compound (34) was prepared from 1.0 ml of 2-amino-5-trifluoromethylpyridine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of furfural solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%), and reaction with acetyl chloride. Excess acetyl chloride was removed under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849642B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-d387b66b0d28469785ad0fe97ff93600 |
| Source note | uspto-grants-2005_02 |