HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2281103Generated: November 2, 2026
Water → 2-[(7-Bromo-5-methyl-quinazolin-4-yl)amino]-5-fluoro-phenol
https://huagongshe.com/reaction/2281103
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | N-(2-benzyloxy-4-fluoro-phenyl)-7-bromo-5-methyl-quinazolin-4-amine | HCID 86718470 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[(7-Bromo-5-methyl-quinazolin-4-yl)amino]-5-fluoro-phenol | HCID 90122472 | — |
Reaction Steps
A mixture of 10 g (22.8 mmol) of N-(2-benzyloxy-4-fluoro-phenyl)-7-bromo-5-methyl-quinazolin-4-amine (Intermediate V.1 step 1) and DCM is cooled to 0° C. and 34.2 ml (34.2 mmol) 1M BBr3 in DCM are added dropwise. After 6 h water is added carefully and the precipitate is filtered off, suspended in water and neutralized with 32% aq. ammonia solution. After 2 h the precipitate is filtered off and dried furnishing 2-[(7-bromo-5-methyl-quinazolin-4-yl)amino]-5-fluoro-phenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09139577B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-72cd1ad572174db9b4072cafd0ff676d |
|---|
| Source note | uspto-grants-2015_09 |
|---|
