HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Di-tert-butylphosphino)biphenyl → 5-Fluoro-2-[[5-methyl-7-[(1-oxothietan-1-ylidene)amino]quinazolin-4-yl]amino]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Reactant | 1-Imino-1lambda6-thietan-1-one | HCID 21684570 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 2-[(7-Bromo-5-methyl-quinazolin-4-yl)amino]-5-fluoro-phenol | HCID 90122472 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Fluoro-2-[[5-methyl-7-[(1-oxothietan-1-ylidene)amino]quinazolin-4-yl]amino]phenol | HCID 117774280 | — |
Reaction Steps
1.5 g (4.3 mmol) 2-[(7-bromo-5-methyl-quinazolin-4-yl)amino]-5-fluoro-phenol, 0.45 g (4.3 mmol) 1-iminothietane 1-oxide (IV.6), 0.26 g (0.86 mmol) 2-(di-t-butylphosphino) biphenyl, 0.3 g (0.33 mmol) Pd2dba3 and 0.61 g (6.4 mmol) sodium tert-butoxide in dioxane are heated to 80° C. for 3 h. After cooling to RT the reaction mixture is filtered and evaporated. The residue is purified by FC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139577B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1c84f241b3364d3fa67417b099ce8b91 |
| Source note | uspto-grants-2015_09 |