(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester → (+/-)-4-((3,3-Dimethylcyclobutyl)((6-fluoro-3-methylquinolin-2-yl)amino)methyl)benzoic acid

HRID 2281161Notes

Reaction equation

HRID 2281161 reaction equation
C([O:3][C:4](=[O:31])[C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH:25]2[CH2:28][C:27]([CH3:30])([CH3:29])[CH2:26]2)[NH:12][C:13]2[C:22]([CH3:23])=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([F:24])[CH:19]=3)[N:14]=2)=[CH:7][CH:6]=1)C.CC1(C)CC(C(NC2C(C)=CC3C(=CC=CC=3)N=2)C2C=CC(C(O)=O)=CC=2)C1>>[CH3:29][C:27]1([CH3:30])[CH2:26][CH:25]([CH:11]([NH:12][C:13]2[C:22]([CH3:23])=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([F:24])[CH:19]=3)[N:14]=2)[C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:31])=[O:3])=[CH:6][CH:7]=2)[CH2:28]1

Participants

3

Reactant 2

HCID 71243734(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester2×HCID 71243837(+/-)-4-[(3,3-Dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid

Product 1

HCID 71243812(+/-)-4-((3,3-Dimethylcyclobutyl)((6-fluoro-3-methylquinolin-2-yl)amino)methyl)benzoic acid

Procedure

The title compound was prepared by treating (+/−)-4-[(3,3-dimethyl-cyclobutyl)-(6-fluoro-3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester (intermediate 72) in a similar as described in the experimental for intermediate 26.

Sources & evidence

ORD record
ord-1107709df0904563b16bdd5deef7b6c1
Source dataset
uspto-grants-2015_09
Patent number
US09139538B2

Reaction notes

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