Quinuclidine, 3-amino-, dihydrochloride → HCID 12985341, compound

HRID 2281185Notes

Reaction equation

HRID 2281185 reaction equation
[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([N:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][C:2]=1[C:15]([OH:17])=O.Cl.Cl.[NH2:20][CH:21]1[CH:26]2[CH2:27][CH2:28][N:23]([CH2:24][CH2:25]2)[CH2:22]1>>[N:23]12[CH2:28][CH2:27][CH:26]([CH2:25][CH2:24]1)[CH:21]([NH:20][C:15]([C:2]1[CH:3]=[CH:4][C:5]3[C:14](=[N:13][C:12]4[C:7]([N:6]=3)=[CH:8][CH:9]=[CH:10][CH:11]=4)[CH:1]=1)=[O:17])[CH2:22]2

Participants

3

Reactant 2

HCID 197853Quinuclidine, 3-amino-, dihydrochlorideHCID 6142242-Phenazinecarboxylic acid

Product 1

HCID 12985341HCID 12985341, compoundYield 25.2%

Procedure

Prepared in analogy to the method for Example 1 starting from 236 mg of phenazine-2-carboxylic acid and 200 mg of 3-aminoquinuclidine dihydrochloride. 84 mg (25% yield) of the free base were obtained after chromatographic separation.

Sources & evidence

ORD record
ord-3fa027f6415b43f9aeb1dec1d6697ac6
Source dataset
uspto-grants-2015_09
Patent number
US09139579B2

Reaction notes

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