HuagongsheHuagongshe Chemistry Print Report · For research reference only
HOAt → HCID 21060090, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HOAt | HCID 181649 | — |
| Reactant | N-Boc-4-chloro-D-phenylalanine | HCID 7018791 | — |
| Reactant | N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide methyliodide | HCID 10236463 | — |
| Reactant | 1-(Piperidin-2-yl)piperazine | HCID 12947145 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21060090 | HCID 21060090 | — |
Reaction Steps
N-{(1R)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-(4-(2-pyridyl)piperazinyl)ethyl}(tert-butoxy)carboxamide was prepared according to the procedure for Preparation XIX using Boc-p-Cl-D-Phe-OH (550 mg, 1.8 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide (1.1 g, 3.80 mmol), HOAT (260 mg, 1.9 mmol), DMF (15 mL), and 1-(2-piperidyl)piperazine (280 μl, 1.8 mmol) (Aldrich). The crude material was concentrated in vacuo to yield 810 mg. MS (ESI, pos. ion) m/z: 445 (M+H), (ESI, neg. ion) m/z: 443 (M−H). Calc'd for C23H29ClN4O3: 444.95.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560460B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-92565239d8c54ba88df919efc21f7775 |
| Source note | uspto-grants-2009_07 |