HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → HCID 68327791, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | 3-Aminoquinuclidine dihydrochloride | HCID 18401282 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68327791 | HCID 68327791 | 548.3% |
Reaction Steps
To a stirred solution of quinuclidin-3-amine hydrochloride (324 mg, 0.199 mmol) in DMF (30 ml) was added triethylamine (3 drops) followed by (isocyanatomethyl)benzene (275 mg, 2.10 mmol) carefully. The resultant mixture was stirred at 25° C. for 18 h. After HPLC separation, 1-benzyl-3-(quinuclidin-3-yl)urea (283 mg, 55%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139580B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-7c15b5a1ac494285a15c76544682a446 |
| Source note | uspto-grants-2015_09 |