反应详情

A solution of the above amide (4.20 g, 25.7 mmol) in POCl3 (36.0 g, 236 mmol) was stirred at 80° C. for 18 h. The solution was concentrated and the residue was poured into water (100 mL). The mixture was exacted with EtOAc. The organic layers were combined, washed by brine, dried over Na2SO4 and concentrated to give 3-isopropyl-benzonitrile (3.00 g, 80%).

1. concentrationThe solution was concentrated
2. additionthe residue was poured into water (100 mL)
3. washwashed by brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated