反应详情

温度

80 °C

A mixture of methyl 5-aminonicotinate (5.0 g, 33 mmol) in acetic acid (47 ml, 820 mmol) was treated with triethyl orthoformate (8.8 ml, 53 mmol), followed by sodium azide (3.2 g, 49 mmol). The resulting mixture was heated at 80° C. for 1 hour, after which the reaction mixture was cooled to room temperature and diluted with water. The resulting precipitate was collected and dried under high vacuum to provide methyl 5-(1H-tetrazol-1-yl)nicotinate.

1. temperatureafter which the reaction mixture was cooled to room temperature
2. customThe resulting precipitate was collected
3. customdried under high vacuum