反应详情

温度

40 °C

A solution of 5-ethenyl-2-(1H-tetrazol-1-yl)pyridine (0.664 g, 3.83 mmol) in a 2:1 ratio of H2O:t-BuOH (30 mL) was treated with N-bromosuccinimide in portions over 5 minutes (0.751 g, 4.22 mmol, 1.1 equiv) and stirred at 40° C. for 1 hour. After cooling to 5° C., the reaction was basified with drop wise addition of solution of sodium hydroxide (0.46 g in 5 mL of H2O, 11.50 mmol, 3 equiv) and stirred for another 1 hour. The reaction mixture was poured into H2O (10 mL) and the product was precipitated out as white solid, filtered, washed with water, dried, yielding the title compound.

1. temperatureAfter cooling to 5° C.
2. stirringstirred for another 1 hour
3. customthe product was precipitated out as white solid
4. filtrationfiltered
5. washwashed with water
6. customdried