2-Pyridinamine, 5-bromo-6-methyl- → 2-Methyl-3-(oxiran-2-yl)-6-(1H-tetrazol-1-yl)pyridine

HRID 2281321Notes

Reaction equation

HRID 2281321 reaction equation
[O:1]1[CH2:3][CH:2]1[C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)=[N:8][CH:9]=1.Br[C:16]1C=CC(N)=NC=1C>>[CH3:16][C:9]1[C:4]([CH:2]2[CH2:3][O:1]2)=[CH:5][CH:6]=[C:7]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)[N:8]=1

Participants

3

Reactant 2

HCID 1706782-Pyridinamine, 5-bromo-6-methyl-HCID 895436045-(Oxiran-2-yl)-2-(1H-tetrazol-1-yl)pyridine2×

Product 1

HCID 895437012-Methyl-3-(oxiran-2-yl)-6-(1H-tetrazol-1-yl)pyridine

Procedure

2-Methyl-3-(oxiran-2-yl)-6-(1H-tetrazol-1-yl) pyridine was prepared in a similar fashion to that described for the synthesis of 5-(oxiran-2-yl)-2-(1H-tetrazol-1-yl)pyridine (INTERMEDIATE 32) starting from 5-bromo-6-methylpyridin-2-amine to provide the title compound.

Workup

  1. custom2-Methyl-3-(oxiran-2-yl)-6-(1H-tetrazol-1-yl) pyridine was prepared in a similar fashion to

Sources & evidence

ORD record
ord-714662dc4a8f426186706133c8ffcaa1
Source dataset
uspto-grants-2015_09
Patent number
US09139585B2

Reaction notes

Loading…