HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Boc-2,5-diazabicyclo[2.2.1]heptane → 5-{(1R)-2-[(1R,4R)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1 (3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Boc-2,5-diazabicyclo[2.2.1]heptane | HCID 11860399 | — |
| Reactant | 4-Methyl-5-((2R)-oxiran-2-yl)-2-benzofuran-1(3H)-one | HCID 59568646 | — |
| Product | 5-{(1R)-2-[(1R,4R)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1 (3H)-one | HCID 117642147 | — |
Reaction Steps
5-{(1R)-2-[(1R,4R)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1 (3H)-one was prepared in an analogous fashion as described for the synthesis of INTERMEDIATE 3 starting from 4-methyl-5-[(2R)-oxiran-2-yl]-2-benzofuran-1 (3H)-one (INTERMEDIATE 2) and commercially available tert-butyl (1R,4R)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139585B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-a1cba4ca97c14aa0ab4782ec29a14dc8 |
| Source note | uspto-grants-2015_09 |