2-Methyl-6-(oxiran-2-yl)nicotinonitrile → 6-(1-Hydroxy-2-{10-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl}ethyl)-2-methylpyridine-3-carbonitrile

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Reaction Steps

6-(1-Hydroxy-2-{10-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl}ethyl)-2-methylpyridine-3-carbonitrile was prepared in a similar fashion to that described for the synthesis of EXAMPLE 1 starting from 5-[(1R)-2-(9,10-diazatricyclo[4.2.1.12,5]dec-9-yl)-1 hydroxyethyl]-4-methyl-2-benzofuran-1 (3H)-one hydrochloride (INTERMEDIATE 9) and 2-methyl-6-(oxiran-2-yl)nicotinonitrile (PCT Published Application WO 2010/129379).

Provenance & Evidence