3-methyl-4-(1H-tetrazol-1-yl)benzene-1-sulfonyl chloride → HCID 71557030, compound

Participants

Reaction Steps

5-((R)-1-Hydroxy-2-((1S,4S)-5-(3-methyl-4-(1H-tetrazol-1-yl)phenylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)-4-methylisobenzofuran-1 (3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 3 starting from 5-((R)-2-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1 (3H)-one hydrochloride (INTERMEDIATE 14) and commercially available 3-methyl-4-(1H-tetrazol-1-yl)benzene-1-sulfonyl chloride.

Provenance & Evidence