反应详情

5-((1R)-2-(5-(4-(1H-Tetrazol-1-yl)phenylsulfonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1 (3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 14 starting from 5-((1R)-2-(2,5-diazabicyclo[2.2.2]octan-2-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one hydrochloride (INTERMEDIATE 16) and commercially available 4-(1H-tetrazol-1-yl)benzene-1-sulfonyl chloride.