反应详情

A solution of 5-[(1R)-2-{4-[2-(1,1-dioxido-1-benzothiophen-5-yl)-2-oxoethyl]piperazin-1-yl}-1-hydroxyethyl]-4-methyl-2-benzofuran-1(3H)-one (56 mg, 0.12 mmol) in DCM (5 mL) was added to a slurry of 10% Pd/C (3.7 mg, 0.30 mmol) in DCM (5 mL). This solution was then subjected to hydrogenation conditions (1 atm @23° C. for 15 hours) and then filtered over a pad of Celite® diatomaceous earth and concentrated in vacuo to afford 5-[(1R)-2-{4-[2-(1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)-2-oxoethyl]piperazin-1-yl}-1-hydroxyethyl]-4-methyl-2-benzofuran-1(3H)-one which was used without further purification.

1. customwas then subjected to hydrogenation conditions (1 atm @23° C. for 15 hours)
2. filtrationfiltered over a pad of Celite® diatomaceous earth
3. concentrationconcentrated in vacuo