4-Piperidinecarboxamide → 1-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Piperidinecarboxamide	HCID 3772	—
Reactant	Triethylamine	HCID 8471	—
Reactant	2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine	HCID 14116871	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	1-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	HCID 57990290	98.8%

Reaction Conditions

Temperature	70 °C

Reaction Steps

A mixture of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (140 mg, 0.744 mmol), isonipecotamide (95 mg, 0.742 mmol) and triethylamine (0.300 mL, 2.15 mmol) in dioxane (4 mL) was stirred at 70° C. for 20 h. The precipitates were collected and dried on vacuum to give 1-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (205 mg). MS 280.3 and 282.3 (M+H, Cl pattern).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09139581B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-d8473095d22b446bacd7e170be0cdfa2
Source note	uspto-grants-2015_09