Water → N-[6-(tetrahydropyranyloxy)hexyl]pyrrole

First, 38.0 g (0.567 mol) of pyrrole and 200 mL of dehydrated tetrahydrofuran (THF) were fed into a 2 liter reactor vessel under a stream of argon gas and cooled to 5° C. or less. Then, 354 mL (0.567 mol) of 1.6M n-butyl lithium hexane solution were dripped into this mixture at 10° C. or less. After stirring for one hour at the same temperature, 600 ml of dimethylsulfoxide were further added, and THFwas removed by distillation by heating for solvent substitution. Then, 165.2 g (0.623 mol) of 6-bromo-1-(tetrahydropyranyloxy)hexane were further dripped at room temperature. After dripping, the mixture was stirred for 2 hours at the same temperature. Then, 600 mol of water were added to the resultant reaction mixture to extract hexane and the organic layer was washed with water. Furthermore, after drying with anhydrous magnesium sulfate, the solvent was removed by distillation. The resultant residues were purified by silica gel column with hexane/ethyl acetate=4/1, and thus 107.0 g of N-[6-(tetrahydropyranyloxy)hexyl]pyrrole were obtained. The yield was 75.2%. Formula (27) below shows the reaction formula of the step 2.

1. temperaturecooled to 5° C. or less
2. customwere dripped into this mixture at 10° C. or less
3. additionwere further added
4. customTHFwas removed by distillation
5. temperatureby heating for solvent substitution
6. customwere further dripped at room temperature
7. customreaction mixture
8. extractionto extract hexane
9. washthe organic layer was washed with water
10. dry with materialFurthermore, after drying with anhydrous magnesium sulfate
11. customthe solvent was removed by distillation
12. customThe resultant residues were purified by silica gel column with hexane/ethyl acetate=4/1

ORD record

ord-f46e9b2a37ea4d58b1c207f0a7851885

Source dataset

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07560731B2