反应详情

To a suspension of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (105 mg, 0.560 mmol) in CH2Cl2 (7 mL) at room temperature, NBS (109 mg, 0.610 mmol) was added. The mixture was stirred at room temperature for 18 h. CH2Cl2 was removed in vacuo. The residue was partitioned between water and EtOAc. The organic phase was separated, washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give 5-bromo-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (142 mg).

1. customCH2Cl2 was removed in vacuo
2. customThe residue was partitioned between water and EtOAc
3. customThe organic phase was separated
4. washwashed with 5% NaHCO3
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo