Selectfluor → 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Selectfluor	HCID 2724933	—
Reactant	2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine	HCID 14116871	—
Solvent	Acetic Acid	HCID 176	—
Solvent	Acetonitrile	HCID 6342	—
Product	2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine	HCID 59442071	22.9%

Reaction Conditions

Temperature	70 °C

Reaction Steps

A mixture of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 1.06 mmol) and SelectFluor (560 mg, 1.58 mmol) in CH3CN (5 mL) and HOAc (1 mL) was stirred at 70° C. for 18 h. The mixture was then concentrated in vacuo. The residue was purified by HPLC to give 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (50 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09139581B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-a1f8d02557bb45978cf9541983ebec41
Source note	uspto-grants-2015_09