참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,2-Dimethyl-1,3-propanediamine | HCID 81770 | — |
| 반응물 | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 14116871 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | N-(3-amino-2,2-dimethylpropyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86636615 | 92.4% |
반응 단계
To 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (170 mg, 0.904 mmol) in solid form in a round-bottom flask, a solution of 2,2-dimethyl-1,3-propanediamine (0.325 mL, 2.71 mmol) and triethylamine (0.150 mL, 1.08 mmol) in nBuOH (4 mL) was added. The mixture was heated at 70° C. for 3 h. It was then purified by HPLC to give N-(3-amino-2,2-dimethylpropyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a solid (212 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09139581B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_09 |
|---|
| ORD ID | ord-5725f552723f4243825cf960a40c22ec |
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| 출처 메모 | uspto-grants-2015_09 |
|---|
