HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzyl chloride → 1-(Methanesulfonylmethyl)-4-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzyl chloride | HCID 7482 | — |
| Reactant | HCID 178504973 | HCID 178504973 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(Methanesulfonylmethyl)-4-nitrobenzene | HCID 287370 | 120.2% |
Reaction Steps
To a mixture of 4-nitrobenzyl chloride (1 g, 5.8 mmol) and TBAI (0.11 g, 0.29 mmol) in EtOH (12 mL) was added NaOSOCH3 (0.77 g, 6.38 mmol). After heating at reflux for 2 h, the mixture was cooled to room temperature, and the precipitates were collected by filtration to give 1-(methylsulfonylmethyl)-4-nitrobenzene (1.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139581B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-129f3f8406d04249bf126bccdb6455a8 |
| Source note | uspto-grants-2015_09 |