4-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE) → 1H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine
Reaction equation
C1([NH:5][C:6]2[C:7]3[CH:31]=[CH:30][NH:29][C:8]=3[N:9]=[C:10]([NH:12]C3C=CC(S(N4CCC(O)CC4)(=O)=O)=CC=3)[N:11]=2)CCC1.CS(CC1C=CC(N)=CC=1)(=O)=O>>[N:9]1[C:8]2[NH:29][CH:30]=[CH:31][C:7]=2[C:6]([NH2:5])=[N:11][C:10]=1[NH2:12]Participants
3
Procedure
According to the general procedure for synthesis of 1-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol, 4-(methylsulfonylmethyl)aniline and 2-Chloro-N-cylclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine gave N4-cyclobutyl-N2-(4-methylsulfonylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine (MS calcd for C18H21N5O2S 371.5. found [MH] 372.1; UV 205.1, 273.6, 304.5 nm).
Sources & evidence
- ORD record
- ord-c456f58d46cc4a449983798cf8a332e8
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09139581B2
Reaction notes
Loading…