Ammonia → 2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine	HCID 14116871	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine	HCID 59892304	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.1 g, 0.53 mmol) in Ammonia (7 N in MeOH, 1 mL) was heated at 100° C. for 24 h, then it was diluted with EtOAc, washed with Sat. NaHCO3, brine, dried and concentrated to give 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-amine (0.06 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09139581B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-03501a093aa144c79d5062695e34fdd9
Source note	uspto-grants-2015_09