HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 1H-Indazol-6-amine | HCID 81423 | — |
| Reactant | 2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 59892304 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine | HCID 44467884 | 12.8% |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
To a mixture of 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-4-amine (0.06 g, 0.353 mmol) in nBuOH (0.7 mL) was added 6-aminoindazole (0.094 g, 0.70 mmol) and TMSCl (0.023 mL, 0.175 mmol). After heating at 115° C. for 8 h, it was cooled and purified by prep HPLC to give N2-(1H-indazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine (0.012 g, MS calcd for C13H11N7 265.3. found 266.1; UV 216.9, 308.0 nm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139581B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-0de07301c87e46e79b3961f8d1cc4756 |
| Source note | uspto-grants-2015_09 |