Chlorotrimethylsilane → 3-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide

참여 물질

역할	이름	HCID	투입량
반응물	Chlorotrimethylsilane	HCID 6397	—
반응물	1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one	HCID 736269	—
반응물	3-(2-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide	HCID 57990401	—
용매	1-Butanol	HCID 263	—
용매	1,4-Dioxane	HCID 31275	—
생성물	3-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide	HCID 57990288	33.7%

반응 조건

온도	110 °C

반응 단계

A mixture of 3-(2-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide (85 mg, 0.19 mmol), 1-(4-(4-aminophenyl)piperazin-1-yl)ethanone (105 mg, 0.480 mmol) and trimethylsilyl chloride (0.030 mL, 0.24 mmol) in dioxane (1 mL) and nBuOH (1 mL) was stirred at 110° C. for 72 h. It was concentrated in vacuo. The residue was purified by HPLC to give 3-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide (40 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09139581B2
출처 데이터셋	uspto-grants-2015_09
ORD ID	ord-86a9488e89764077b549ea1b481e4b2c
출처 메모	uspto-grants-2015_09