HRID2281533

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1514304

4-Cbz-aminopiperidine

C13H18N2O2

结构：CC(=O)N1CCN(c2ccc(Nc3ncc(F)c(N4CCC(CN)CC4)n3)cc2)CC1

HCID44467319

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCN(c2ccc(Nc3ncc(F)c(N4CCC(NC(=O)OCc5ccccc5)CC4)n3)cc2)CC1

HCID44467167

未命名化合物

PROCEDURE

实验过程

The titled compound was synthesized analogously as compound 1-(4-(4-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone, by using benzyl piperidin-4-ylcarbamate. MS 548.4 (M+H); UV 215.8, 258.8, 279.8 nm.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a07c752ad39040f98ac971db525ae859
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09139581B2
来源说明: uspto-grants-2015_09

反应 SMILES

NC[CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1.N1CCC([NH:38][C:39](=[O:48])[O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)CC1>>[C:29]([N:26]1[CH2:25][CH2:24][N:23]([C:20]2[CH:19]=[CH:18][C:17]([NH:16][C:11]3[N:10]=[C:9]([N:6]4[CH2:7][CH2:8][CH:3]([NH:38][C:39](=[O:48])[O:40][CH2:41][C:42]5[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=5)[CH2:4][CH2:5]4)[C:14]([F:15])=[CH:13][N:12]=3)=[CH:22][CH:21]=2)[CH2:28][CH2:27]1)(=[O:31])[CH3:30]