4-Aminobenzoic Acid → HCID 44467241, compound

HRID 2281537Notes

Reaction equation

HRID 2281537 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20](N4CCN(C(=O)C)CC4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1.NC1C=CC([C:37]([OH:39])=[O:38])=CC=1>>[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([C:37]([OH:39])=[O:38])=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 9784-Aminobenzoic AcidHCID 444673191-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Product 1

HCID 44467241HCID 44467241, compound

Procedure

The titled compound was synthesized analogously as compound 1-(4-(4-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone, by using 4-aminobenzoic acid. MS 346.2 (M+H); UV 215.8, 275.8, 292.8 nm.

Sources & evidence

ORD record
ord-6dac9677ea1940e0b7320fcce688bca1
Source dataset
uspto-grants-2015_09
Patent number
US09139581B2

Reaction notes

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