HRID2281573

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85247

Silane, iodotrimethyl-

C3H9ISi

$结构：Nc1nc(N)c(C(=O)/N=C2\NC[C@H](CCCNC(=O)OCc3ccccc3)N2)nc1Cl$

HCID178508794

未命名化合物

PRODUCTS

生成物

$结构：NCCC[C@H]1CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N1$

HCID178511031

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of (3-{(S)-2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-imidazolidin-4-yl}-propyl)-carbamic acid benzyl ester (Ex. 30) (0.44 g, 0.98 mmol) in DCM (20 ml) is added iodotrimethylsilane (0.27 ml, 1.96 mmol) in a dropwise manner. The orange suspension is stirred at room temperature for 65 minutes. Purification by catch and release resin (SCX-2) eluting with MeOH followed by 7M NH3 in MeOH yields the title compound as a yellow foam; [M+H]+ 313.1

WORKUP

后处理

customPurification by catch and release resin (SCX-2)
washeluting with MeOH