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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2281621Generated: October 30, 2026

methyl 1H-indole-4-carboxylate → 1-Isopropylcarbamoyl-1H-indole-4-carboxylic acid

https://huagongshe.com/reaction/2281621

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl 1H-indole-4-carboxylateHCID 2733668—
ReactantEthyl 2-aminopyridine-4-carboxylateHCID 7015521—
Reactant2-(3-Isopropyl-ureido)-isonicotinic acidHCID 64393466—
Product1-Isopropylcarbamoyl-1H-indole-4-carboxylic acidHCID 67086834—

Reaction Steps

This compound is prepared analogously to Intermediate Y by replacing ethyl 2-aminoisonicotinate in step 1 with methyl indol-4-carboxylate; [M+H]+ 247

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09139586B2
Source datasetuspto-grants-2015_09
ORD IDord-77d1c92688a6407dbe4979ef9ec8f195
Source noteuspto-grants-2015_09