Sodium Hydroxide → HCID 67086703, compound

HRID 2281625Notes

Reaction equation

HRID 2281625 reaction equation
C[O:2][C:3](=[O:18])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:7][CH:6]=1.[OH-].[Na+]>CO>[CH3:17][O:16][CH2:15][CH2:14][O:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:18])=[O:2])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11470803HCID 11470803, compound

Product 1

HCID 67086703HCID 67086703, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [4-(2-Methoxy-ethoxymethoxy)-phenyl]-acetic acid methyl ester (192 mg, 0.76 mmol) in MeOH (3 ml) is added 2 M NaOH (3 ml). The reaction mixture is stirred for 16 hours at room temperature. The solvent is removed in vacuo and the residue dissolved in EtOAc and washed with sat. aq. NH4Cl solution, dried (MgSO4) and concentrated in vacuo to yield [4-(2-Methoxy-ethoxymethoxy)-phenyl]-acetic acid

Workup

  1. customThe solvent is removed in vacuo
  2. dissolutionthe residue dissolved in EtOAc
  3. washwashed with sat. aq. NH4Cl solution
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e0ec3c8c0a2c469698d40ca1a909119b
Source dataset
uspto-grants-2015_09
Patent number
US09139586B2

Reaction notes

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