Acetone Cyanohydrin → 2-Methyl-2-(morpholin-4-yl)propanenitrile

HRID 2281802Notes

Reaction equation

HRID 2281802 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>CC(C)=O>[CH3:1][C:2]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)([CH3:6])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 8083Morpholine

Product 1

HCID 24237842-Methyl-2-(morpholin-4-yl)propanenitrile

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Acetone cyanohydrin (4.3 g, 50 mmol) was dissolved into acetone (5 mL). Morpholine (4.3 g, 50 mmol) was added and the solution was stirred at rt for 24 h. The volatile solvents were removed in vacuo to give the title compound as a clear liquid in quantitative yield. MS ESI 155.0 [M+H]+, calcd for [C8H14N2O+H]+ 155.1.

Workup

  1. customThe volatile solvents were removed in vacuo

Sources & evidence

ORD record
ord-7735ed3d8c8c4c8db4c06daa0e189980
Source dataset
uspto-grants-2015_09
Patent number
US09139563B2

Reaction notes

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