HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzaldehyde → (R)-1-(4-bromobenzyl)-3-fluoropyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | (3R)-3-fluoropyrrolidine hydrochloride | HCID 2759162 | — |
| Product | (R)-1-(4-bromobenzyl)-3-fluoropyrrolidine | HCID 66730391 | — |
Reaction Steps
The title compound was synthesized according to the method of Example A105B, except substituting (R)-3-fluoropyrrolidine hydrochloride (576 mg, 4.59 mmol) and 4-bromobenzaldehyde (849 mg, 4.59 mmol) which gave 1.09 g, 91% of a clear, colourless oil; MS ESI [M+H]+ 258.0, calcd for [C11H13BrFN+H]+ 258.03.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139563B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-bd583b027cb045f38baa8c3ebedae49b |
| Source note | uspto-grants-2015_09 |