Formic Acid → HCID 67151216, compound

Participants

Reaction Steps

3,4-diamino-5-chlorobenzoate (1.2 g, 6 mmol) was added to water (10 mL) and formic acid (826 mg, 18 mmol) and heated at reflux for 4 hours. The reaction was cooled to ambient temperature and aqueous potassium hydroxide was added (21 mL, 1M). The reaction solution was washed with ethyl acetate (2×25 mL each). The aqueous layer was acidified to pH=5 with aqueous hydrochloric acid (1N) to give a precipitate which was filtered, washed with water and dried under a stream of nitrogen to give the title compound (439 mg, 37%). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.45 (s, 1 H) 8.10 (d, J=1.17 Hz, 1 H) 7.77 (d, J=1.37 Hz, 1 H).

Provenance & Evidence