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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 228187Generated: October 27, 2026

4-Hydroxybenzaldehyde → 3-Chloro-4-(4-formylphenoxy)benzonitrile

https://huagongshe.com/reaction/228187

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxybenzaldehydeHCID 126—
Reactant3-Chloro-4-fluorobenzonitrileHCID 145525—
Product3-Chloro-4-(4-formylphenoxy)benzonitrileHCID 568514251.91%

Reaction Steps

The above compound is prepared by nucleophilic displacement reaction of 4-hydroxy benzaldehyde and 3-chloro-4-fluorobenzonitrile under basic conditions as described in Example 243, step 1.91% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07560463B2
Source datasetuspto-grants-2009_07
ORD IDord-3542ec29f7764344a18100c91e26ad7b
Source noteuspto-grants-2009_07