HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Methyl 2-(chlorocarbonyl)pyridine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(Methoxycarbonyl)pyridine-2-carboxylic acid | HCID 13353752 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(chlorocarbonyl)pyridine-4-carboxylate | HCID 45081772 | — |
Reaction Steps
To 4-(methoxycarbonyl)picolinic acid (150 g, 1.62 mol) in dichloromethane (500 mL) was added oxalyl chloride (400 mL) keeping the temperature at 25-30° C. for 3 days. The reaction was evaporated in vacuo to afford methyl 2-(chlorocarbonyl)isonicotinate as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139587B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-757ace36b88a4f9194c1125f4ea59229 |
| Source note | uspto-grants-2015_09 |