HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl (z)-2-((((1-aminoethylidene)amino)oxy)carbonyl)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (E)-N'-Hydroxyacetimidamide | HCID 5487681 | — |
| Reactant | Methyl 2-(chlorocarbonyl)pyridine-4-carboxylate | HCID 45081772 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl (z)-2-((((1-aminoethylidene)amino)oxy)carbonyl)isonicotinate | HCID 87287813 | — |
Reaction Steps
To a solution of methyl 2-(chlorocarbonyl)isonicotinate in dichloromethane (500 mL) was added (Z)—N′-hydroxyacetimidamide and triethylamine, keeping the temperature at 25-30° C. for 1 day. The reaction was concentrated in vacuo to afford (Z)-methyl 2-((1-aminoethylideneaminooxy)carbonyl)isonicotinate as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139587B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1b07a31456f64813b0fb9f0ac5955a0e |
| Source note | uspto-grants-2015_09 |