HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl (z)-2-((((1-aminoethylidene)amino)oxy)carbonyl)isonicotinate → Methyl 2-(3-methyl-1,2,4-oxadiazol-5-yl)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl (z)-2-((((1-aminoethylidene)amino)oxy)carbonyl)isonicotinate | HCID 87287813 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-(3-methyl-1,2,4-oxadiazol-5-yl)isonicotinate | HCID 67151212 | — |
Reaction Steps
A solution of (Z)-methyl 2-((1-aminoethylideneaminooxy)carbonyl)isonicotinate in toluene (1 L) was heated at reflux overnight. The obtained mixture was evaporated and purified by silica-gel column chromatography to afford methyl 2-(3-methyl-1,2,4-oxadiazol-5-yl)isonicotinate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139587B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-662d318e3d354c7eb1f2e9e0ee13b7e0 |
| Source note | uspto-grants-2015_09 |