Methylurea → HCID 816901, compound

HRID 2281930Notes

Reaction equation

HRID 2281930 reaction equation
[C:1](C(CC)C(OCC)=O)#N.CNC(N)=O.[NH2:16][C:17]1[N:22]([CH2:23]C)[C:21](=[O:25])[NH:20][C:19](=[O:26])[C:18]=1[CH3:27]>>[NH2:16][C:17]1[N:22]([CH3:23])[C:21](=[O:25])[NH:20][C:19](=[O:26])[C:18]=1[CH2:27][CH3:1]

Participants

4

Reactant 3

HCID 11719MethylureaHCID 219611ethyl 2-cyanobutanoateHCID 117772300HCID 117772300, compound

Product 1

HCID 816901HCID 816901, compound

Procedure

Ethyl 2-cyanobutanoate was reacted with 1-methylurea according to the method described for synthesis of C9 in Example 5. The product was obtained as a white solid. Yield: 5.95 g, 35.2 mmol, 66%. 1H NMR (400 MHz, DMSO-d6) δ 10.36 (s, 1H), 6.41 (s, 2H), 3.22 (s, 3H), 2.22 (q, J=7.3 Hz, 2H), 0.87 (t, J=7.3 Hz, 3H).

Workup

  1. customThe product was obtained as a white solid

Sources & evidence

ORD record
ord-25ed5c1b25114034834fd039c6a89e34
Source dataset
uspto-grants-2015_09
Patent number
US09139561B2

Reaction notes

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