Acetaldehyde → 4-(1H-imidazol-1-yl)butan-1-amine

HRID 2281964Notes

Reaction equation

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[NH2:6][CH2:7][C@@H:8]1[CH2:12][CH2:11]CN1CC.C(=O)C>>[N:1]1([CH2:11][CH2:12][CH2:8][CH2:7][NH2:6])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

Reactant 3

HCID 177Acetaldehyde

HCID 795Imidazole

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

Product 1

HCID 43794804-(1H-imidazol-1-yl)butan-1-amine

Procedure

By using imidazole (2.00 g) as a starting material, the title compound (0.37 g) was obtained in the same manners as those of Reference Example 63, (1) and Reference Example 9, (2).

Sources & evidence

ORD record: ord-7ede9229473f4076a5a3ac388d371a34
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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