Acetaldehyde → HCID 58959829, compound

HRID 2281967Notes

Reaction equation

C(OC([NH:8][C@@H:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=O)(C)(C)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16].NC[C@@H]1CCCN1CC.C(=O)C>>[CH3:14][S:15]([N:11]1[CH2:12][CH2:13][C@@H:9]([NH2:8])[CH2:10]1)(=[O:17])=[O:16]

Participants

Reactant 4

HCID 177Acetaldehyde

HCID 31297Methanesulfonyl chloride

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 58959829HCID 58959829, compound

Procedure

By using (R)-(+)-3-(t-butoxycarbonylamino)pyrrolidine (2.0 g) and methanesulfonyl chloride (1 ml) as starting materials, the title compound (0.98 g) was obtained in the same manners as those of Reference Example 58, (1) and Reference Example 39, (2).

Sources & evidence

ORD record: ord-9b8d77973e6e4ab8893ad6f0cdbee716
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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