Acetaldehyde → HCID 58959830, compound

HRID 2281968Notes

Reaction equation

C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=O)(C)(C)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16].NC[C@@H]1CCCN1CC.C(=O)C>>[CH3:14][S:15]([N:11]1[CH2:12][CH2:13][C@H:9]([NH2:8])[CH2:10]1)(=[O:17])=[O:16]

Participants

Reactant 4

HCID 177Acetaldehyde

HCID 31297Methanesulfonyl chloride

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 58959830HCID 58959830, compound

Procedure

By using (S)-(−)-3-(t-butoxycarbonylamino)pyrrolidine (2.0 g) and methanesulfonyl chloride (1 ml) as starting materials, the title compound (1.03 g) was obtained in the same manners as those of Reference Example 58, (1) and Reference Example 39, (2).

Sources & evidence

ORD record: ord-6155a36c42ae46618b607cc9eef2a68f
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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