Acetaldehyde → HCID 62062682, compound

HRID 2281969Notes

Reaction equation

C(OC([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][NH:12][CH2:11]1)=O)(C)(C)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17].NC[C@@H]1CCCN1CC.C(=O)C>>[CH3:15][S:16]([N:12]1[CH2:13][CH2:14][CH:10]([CH2:9][NH2:8])[CH2:11]1)(=[O:18])=[O:17]

Participants

Reactant 4

HCID 177Acetaldehyde

HCID 31297Methanesulfonyl chloride

HCID 643457(S)-(-)-2-Aminomethyl-1-ethylpyrrolidine

HCID 4250767tert-butyl N-((pyrrolidin-3-yl)methyl)carbamate

Product 1

HCID 62062682HCID 62062682, compound

Procedure

By using 3-(t-butoxycarbonylaminomethyl)pyrrolidine (1.0 g) and methanesulfonyl chloride (0.48 ml) as starting materials, the title compound (0.78 g) was obtained in the same manners as those of Reference Example 58, (1) and Reference Example 39, (2).

Sources & evidence

ORD record: ord-b87d1bc7d0de4b648a1713b7e14931a7
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139609B2

Reaction notes

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