Sodium Bicarbonate → Oxycodone

Participants

Reaction Steps

Oxycodone-hydrochloride (21.0 g, 59.7 mmol) was dissolved in water (250 mL). This solution was basified with saturated aqueous NaHCO3 (to pH 8-9) and extracted with DCM (3×250 mL). The combined organic layer was dried over Na2SO4 and filtered; removal of solvents under vacuum afforded Compound L in 98% yield (18.5 g, 58.8 mmol) as a white solid. LC-MS [M+H] 316.1 (C18H21NO4+H, calc: 316.2). Compound L was used directly in the next reaction without further purification.

Provenance & Evidence