HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-Bromo-4-[(2,2-dimethoxyethyl)sulfanyl]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromothiophenol | HCID 66049 | — |
| Reactant | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Bromo-4-[(2,2-dimethoxyethyl)sulfanyl]benzene | HCID 14175760 | — |
Reaction Steps
NaH (1.2 g, 20.5 mmol, 60% in mineral oil) was added to a dry THF (20 ml) solution of 4-bromobenzene thiol (3.0 g, 15.8 mmol) and reacted at room temperature for 10 minutes. Next, bromoacetaldehyde dimethyl acetal (2.8 mL, 23.7 mmol) was added to the mixture and reacted while being refluxed for two days.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139774B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-9bc42db7bd3749f1bf9b6d2e6ecfa9a9 |
| Source note | uspto-grants-2015_09 |